https://www.makaibio.com/our-team daily 0.75 2025-08-27 https://images.squarespace-cdn.com/content/v1/5ef63f2d8ce89d0690574d3a/608bf7df-5620-4167-b96b-6fb4705b68bf/IMG_3458_v4.jpg Our Team https://images.squarespace-cdn.com/content/v1/5ef63f2d8ce89d0690574d3a/1593208824549-ZBY31OJEHMXYH4JDTG3U/image.png Our Team https://images.squarespace-cdn.com/content/v1/5ef63f2d8ce89d0690574d3a/1593208943968-H57EDBU0NU416DYPHNK5/Screen+Shot+2020-06-26+at+12.01.43+PM.png Our Team https://images.squarespace-cdn.com/content/v1/5ef63f2d8ce89d0690574d3a/7f5996b0-cb19-498a-a5b7-012517889f8d/planet-earth-globe-in-shape-a-red-heart-vector-24902850.jpg Our Team - We collaborate with scientists across the world to advance ion channel and heart failure research. Dr. Helen Turner Chaminade University, Hawaii Ion channel physiology and electrophysiology Dr. Andrea Small-Howard GB Sciences, Nevada Cannabinoid and terpene TRPV1 therapeutics Dr. Yasuo Mori Kyoto University, Japan TRP channel physiology and regulation Dr. Chaker Adra The Adra Institute, Boston, MA Pathology and physiology https://www.makaibio.com/our-technology daily 0.75 2020-11-11 https://images.squarespace-cdn.com/content/v1/5ef63f2d8ce89d0690574d3a/1605134716768-OE182LKQ7CB4PDPAOHX8/Screen+Shot+2020-11-11+at+12.44.29+PM.png Technology and Business Development We have completed in vitro mechanistic studies and in vivo proof of concept studies in murine models. https://images.squarespace-cdn.com/content/v1/5ef63f2d8ce89d0690574d3a/1605136822078-4WZPWEP5WLQC03DB7J26/Screen+Shot+2020-11-11+at+1.19.40+PM.png Technology and Business Development Makai BiotechnologY Business Development Strategy Overview https://www.makaibio.com/contact-us daily 0.75 2026-01-06 https://www.makaibio.com/heart-failure daily 0.75 2020-11-11 https://images.squarespace-cdn.com/content/v1/5ef63f2d8ce89d0690574d3a/1593205515147-A1T1PAFZLM7ESUMUC0YF/Screen+Shot+2020-06-26+at+11.01.18+AM.png Heart Failure The process of heart failure https://www.makaibio.com/about daily 0.75 2020-11-11 https://www.makaibio.com/home daily 1.0 2023-05-09 https://images.squarespace-cdn.com/content/v1/5d375649e2ffc000016e0aec/1572716064535-TQDLAWAE3QNNULKXJRR4/20140228_Trade%252B151_0067%252B%25281%2529.jpg Home - The TRPV1 ion channel controls heart failure progression at the molecular level. We have figured out a way to safely suppress its activity. We have shown conclusively, in animal studies, the this approach not only stops heart failure in its tracks but can reverse the damage. This is unprecedented, and we have convened a world-class team to place new TRPV1-targeted therapies for heart failure into the hands of physicians and patients worldwide. https://www.makaibio.com/heart-health-resources daily 0.75 2020-06-26 https://images.squarespace-cdn.com/content/v1/5ef63f2d8ce89d0690574d3a/1593199050440-TIL7BKKX1C019KXF40MQ/image.png Heart Health Resources - According to a 2017 survey from the Cleveland Clinic, almost 70 percent of Americans are afraid of dying of heart disease. Despite this, only 38 percent know their blood pressure, and just 18 percent know their body mass index (BMI), which are essential factors in overall heart health. So, it's clear that more Americans need to learn about heart health and how to manage it/ — Talk to your physician today https://images.squarespace-cdn.com/content/v1/5ef63f2d8ce89d0690574d3a/1593199288640-558UFHRQVF1VCPZUDNUQ/Unknown.png Heart Health Resources - Cardiovascular disease is the No. 1 killer of women, causing 1 in 3 deaths each year. The AAmerican Heart Association regularly release guidance for women at risk for heart attack and stroke, and is actively funding research into gender-based differences in in cidence and outcomes of cardiovascular disease. —Go Red for Women.: American Heart Association https://www.heart.org/en/news/category-womens-health https://images.squarespace-cdn.com/content/v1/5ef63f2d8ce89d0690574d3a/1593199560237-IUW25M65DYS4O9B9CM9K/Unknown.jpeg Heart Health Resources - 6 strategies to lead a heart healthy life — Eat a healthy diet Move more, sit less Learn your heart health family history and tell your doctor Quit smoking Take medicines as directed Decrease sugary drink consumption https://www.cdc.gov/chronicdisease/resources/infographic/hearthealth.htm https://images.squarespace-cdn.com/content/v1/5ef63f2d8ce89d0690574d3a/1593199987004-FHBXBL4YIZRS9YQWGQDS/Unknown-1.jpeg Heart Health Resources - Think about monitoring Knowledge is power…….. https://www.makaibio.com/papers-and-patent daily 0.75 2020-06-26 https://images.squarespace-cdn.com/content/v1/5ef63f2d8ce89d0690574d3a/1593203836655-XF8489ROILSDKNF9A7AR/image.png Papers and Patent - US20170231982A1 Methods and compositions for prevention and treatment of cardiac hypertrophy https://www.hawaii.edu/news/2015/08/25/heart-failure-therapy-patent-awarded-to-medical-school-researcher/ https://www.bizjournals.com/pacific/news/2015/08/14/university-of-hawaii-medical-school-researcher.html https://www.linkedin.com/pulse/gb-sciences-licenses-patent-from-makai-biotechnology-develop-stokes/ https://images.squarespace-cdn.com/content/v1/5ef63f2d8ce89d0690574d3a/1593204000957-NU1XULOJZAONU6UU6ICC/nih-logo.png Papers and Patent - Grants that have funded our research NIH U54MD007584 RMATRIX (Research Centers in Minority Institutions. Multidisciplinary And Translational Research Infrastructure Expansion) NIH BRIC P20 MD0006084 (Biomedical Research Infrastructure and Capacity Building) Hawaii Community Foundation Geist Foundation for Medical Research NIH COBRE P20GM113134 (Center for Biomedical Research Excellence) NIH INBRE P20RR016467 (IDeA Network for Biomedical Research Excellence) https://www.makaibio.com/take-action daily 0.75 2025-05-09